Analyzing clinical data in XML: Bridging the gaps
Joshua Hui, Sarah Knoop, et al.
IHI 2012
Recent studies show gut microbiota modulate antitumor immune responses; one proposed mechanism is cross-reactivity between antigens expressed in commensal bacteria and neoepitopes. We found that T cells targeting an epitope called SVYRYYGL (SVY), expressed in the commensal bacterium Bifidobacterium breve (B. breve), cross-react with a model neoantigen, SIYRYYGL (SIY). Mice lacking B. breve had decreased SVY-reactive T cells compared with B. breve-colonized mice, and the T cell response was transferable by SVY immunization or by cohousing mice without Bifidobacterium with ones colonized with Bifidobacterium. Tumors expressing the model SIY neoantigen also grew faster in mice lacking B. breve compared with Bifidobacterium-colonized animals. B. breve colonization also shaped the SVY-reactive TCR repertoire. Finally, SVY-specific T cells recognized SIY-expressing melanomas in vivo and led to decreased tumor growth and extended survival. Our work demonstrates that commensal bacteria can stimulate antitumor immune responses via cross-reactivity and how bacterial antigens affect the T cell landscape.
Joshua Hui, Sarah Knoop, et al.
IHI 2012
Carlos F. G. C. Geraldes, Rodney D. Brown, et al.
Magnetic Resonance in Medicine
Daniel Darvish
Medical Hypotheses
D.A. Shirley, Yu Zheng, et al.
Journal of Electron Spectroscopy and Related Phenomena