Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

Zhan Yuin Ong; Daniel J. Coady; Jeremy P. K. Tan; Yan Li; Julian Chan; Yi Yan Yang; James L. Hedrick

doi:10.1002/pola.27987

J Polym Sci Part A

Paper

27 Nov 2015

Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

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Abstract

Several biodegradable grafted cationic polycarbonates prepared via metal-free organocatalytic ring-opening polymerization are investigated for their antimicrobial activity, mechanism of action, and biocompatibility.

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Catalytic insights into acid/base conjugates: Highly selective bifunctional catalysts for the ring-opening polymerization of lactide

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Antimicrobial polycarbonates: Investigating the impact of balancing charge and hydrophobicity using a same-centered polymer approach

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Tuning the Selectivity of Biodegradable Antimicrobial Cationic Polycarbonates by Exchanging the Counter-Anion

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Abstract

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Mitigated cytotoxicity and tremendously enhanced gene transfection efficiency of PEI through facile one-step carbamate modification

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