Huajun Chen, Guotong Xie
Expert Opinion on Drug Discovery
Background: Emergence of vaccine-escaping SARS-CoV-2 variants is a serious problem for global public health. The currently rampant Omicron has been shown to possess remarkable vaccine escape; however, the selection pressure exerted by vaccines might pave the way for other escape mutants in the near future. Materials & methods: For detection of neutralizing antibodies, the authors used the recently developed HiBiT-based virus-like particle neutralization test system. Sera after vaccination (two doses of Pfizer/BioNTech mRNA vaccine) were used to evaluate the neutralizing activity against various strains of SARS-CoV-2. Results: Beta+R346K, which was identified in the Philippines in August 2021, exhibited the highest vaccine resistance among the tested mutants. Surprisingly, Mu+K417N mutant exhibited almost no decrease in neutralization. Imdevimab retained efficacy against these strains. Conclusions: Mutations outside the receptor-binding domain contributed to vaccine escape. Both genomic surveillance and phenotypic analysis synergistically accelerate identifications of vaccine-escaping strains.
Huajun Chen, Guotong Xie
Expert Opinion on Drug Discovery
Colm T. Whelan, R.K. Nesbet, et al.
Journal of Electron Spectroscopy and Related Phenomena
Uri Kartoun, Kingsley Njoku, et al.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Esraa Omran, Tyrone Grandison, et al.
World Congress on Medical Informatics 2010