Exceptionally easy isomerization of acetylenic alcohols with potassium 3-aminopropylamide. A new, high yield synthesis of functionally differentiated αω-difunctional structures

Charles Allan Brown; A. Yamashita

doi:10.1039/C39760000959

Journal of the Chemical Society, Chemical Communications

Paper

01 Dec 1976

Exceptionally easy isomerization of acetylenic alcohols with potassium 3-aminopropylamide. A new, high yield synthesis of functionally differentiated αω-difunctional structures

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Abstract

Potassium 3-aminopropylamide, readily prepared in situ from KH and 3-aminopropylamine, effects rapid, multipositional isomerization of the triple bond in prop-2-ynylic and other acetylenic alcohols to the chain terminus remote from the hydroxy function, within minutes at 0-20 °C.

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