Vikram Mitra, Age Smilde, et al.
Journal of Chromatography A
We present a 118-ns molecular dynamics simulation of rhodopsin embedded in a bilayer composed of a 2:2:1 mixture of 1-stearoyl-2-docosahexaenoyl-phosphatidylcholine (SDPC), 1-stearoyl-2-docosahexaenoyl-phosphatidylethanolamine (SDPE), and cholesterol, respectively. The simulation demonstrates that the protein breaks the lateral and transverse symmetry of the bilayer. Lipids near the protein preferentially reorient such that their unsaturated chains interact with the protein, while the distribution of cholesterol in the membrane complements the variations in rhodopsin's transverse profile. The latter phenomenon suggests a molecular-level mechanism for the experimental finding that cholesterol stabilizes the native dark-adapted state of rhodopsin without binding directly to the protein. Copyright © 2005 American Chemical Society.
Vikram Mitra, Age Smilde, et al.
Journal of Chromatography A
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ISGT-Asia 2016
Pick-Wei Lau, Alan Grossfield, et al.
Journal of Molecular Biology
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IEEE Transactions on Smart Grid