Bioorganic and Medicinal Chemistry Letters

Paper

01 Jan 1993

Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase

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Abstract

A series of four side-chain unsaturated histamine analogs were synthesized and evaluated as inhibitors of Diamine Oxidase, (DAO). All four target compounds were potent competitive inhibitors of DAO with Ki values ranging from 0.17 to 7.1 μM. © 1993.

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