Shabnam Khatibi, Hong-Jian Zhu, et al.
BMC Systems Biology
Mathematical models for TGF-β and IL-6 signalling have been linked, providing a platform for analyzing the crosstalk between the systems. An integrated IL-6:TGF-β model was developed via a reduced set of reaction equations which incorporate both feedback loops and appropriate time-delays for transcription and translation processes. The model simulates stable, robust and realistic responses to both ligands. Pulsatile (multiple pulses) inputs for both TGF-β and IL-6 have been simulated to investigate the effects of each ligand on the sensitivity, equilibrium and dynamic responses of the integrated signalling system. In our simulations the crosstalk between constant IL-6 and TGF-β signalling via SMAD7 does not appear to be sufficient to render the cells resistant to TGF-β inhibition. However, the simulations predict that pulsatile IL-6 stimulation would increase SMAD7 levels substantially and consequentially, lead to resistance to TGF-β. The model also allows the prediction of the integrated signalling pathway responses to the mutation of key components, e.g. Gp130 F/F.
Shabnam Khatibi, Hong-Jian Zhu, et al.
BMC Systems Biology
James Kozloski, John Wagner
Frontiers in Neuroinformatics
Daniel K. Weber, Shenggen Yao, et al.
Biophysical Journal
Hoang Tam Vo, Ziyuan Wang, et al.
iThings/GreenCom/CPSCom/SmartData/Blockchain/CIT 2018