An artificial nose based on a micromechanical cantilever array
H.P. Lang, M.K. Baller, et al.
Analytica Chimica Acta
We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable. Similar experiments on protein A-immunoglobulin interactions demonstrate the wide-ranging applicability of nanomechanical transduction to detect biomolecular recognition.
H.P. Lang, M.K. Baller, et al.
Analytica Chimica Acta
R. Berger, E. Delamarche, et al.
Applied Physics A: Materials Science and Processing
H.P. Lang, J.P. Ramseyer, et al.
Ultramicroscopy
J. Karpinski, H. Schwer, et al.
Applied Superconductivity